科研项目: |
1.国家自然科学基金青年基金 基于协同进化原则的蛋白质结构域重组 策略及其在构建超嗜热脂肪酶中的应用(项目编号:31400681) 2015.1-2017.12 2.吉林省科技厅青年科研基金 蛋白质结构域重组构建新型热稳定丝氨 酸蛋白酶抑制剂(项目编号:20160520142JH)2016.1-2018.12 3.吉林省卫生计生青年科研课题 嗜热丝氨酸蛋白酶抑制剂Pnserpin的 结构功能及抗炎活性研究(项目编号:2015Q016)2016.1-2017.12 4.吉林省择优资助博士后科研项目 以丙酮酸脱氢酶激酶为靶点的药物 筛选及抗肿瘤作用研究2016.1-2017.12 5.澳门太阳集团9728白求恩计划项目青年基金 蛋白质结构域重组构建新型嵌合 丝氨酸蛋白酶抑制剂(项目编号:2015424)2016.1-2017.12 |
学术论文: |
1. Xiaoli Zhou , Shanshan Yu, Jing Su and Liankun Sun. Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases. Int. J. Mol. Sci. 2016, 17(3):340. 2. Xiaoli Zhou, Le Gao, Guangyu Yang, Donglai Liu, Aixi Bai, Binchun Li, Zixin Deng, Yan Feng. Design of hyperthermophilic lipase chimeras by Key Motif-Directed Recombination. Chembiochem. 2015, 16(3):455-462. 3. Xiao-Li Zhou, Ming Yang, Bai-Gong Xue, Hai-Tao He, Chun-Mei Zhang, Miao-Miao Liu, Li-Jiao Zhang, Rui Fei. Anti-inflammatory action of Ginkgo Biloba leaf polysaccharide via TLR4/NF-κb signaling suppression. Biomedical Research-india 2014, 25 (4), 449-454. 4. Xiaoli Zhou, Weiwei Han, Baisong Zheng, Yan Feng. Insight into Substrate Preference of Two Chimeric Esterases by Combining Experiment and Molecular Simulation. Chem. Res. Chin. Univ. 2013, 29(3), 533-537. 5. Xiaoli Zhou, Honglei Wang, Yuhang Zhang, Le Gao, Yan Feng.Alteration of substrate specificities of thermophilic alpha/beta hydrolases through domain swapping and domain interface optimization. Acta Biochim Biophys Sin. 2012, 44(12), 965-973. |